Unraveling the mechanisms of deep-brain stimulation of the internal capsule in a mouse model

Unraveling the mechanisms of deep-brain stimulation of the internal capsule in a mouse model

Blog Article

Abstract Deep-brain stimulation (DBS) is an lock shock and barrel art effective treatment for patients suffering from otherwise therapy-resistant psychiatric disorders, including obsessive-compulsive disorder.Modulation of cortico-striatal circuits has been suggested as a mechanism of action.To gain mechanistic insight, we monitored neuronal activity in cortico-striatal regions in a mouse model for compulsive behavior, while systematically varying clinically-relevant parameters of internal-capsule DBS.DBS showed dose-dependent effects on both brain and behavior: An increasing, yet balanced, number of excited and inhibited neurons was recruited, scattered throughout cortico-striatal regions, while excessive grooming decreased.

Such neuronal recruitment did not alter basic brain function such as resting-state activity, and only occurred in awake animals, indicating a dependency on network activity.In addition to these widespread effects, we observed specific involvement of the medial orbitofrontal cortex in therapeutic outcomes, which was corroborated viqua-f4 by optogenetic stimulation.Together, our findings provide mechanistic insight into how DBS exerts its therapeutic effects on compulsive behaviors.